Lungs are exposed to external oxidants from the environment as in harmful particles and smog. causing oxidative stress in the lungs and consequently respiratory ailment. The NF-E2-related factor 2 (Nrf2) is the one with transcriptional regulatory function. while its related protein Kelch-like ECH-associated protein 1 (Keap1) inhibits Nrf2 activity. https://www.foldlyers.shop/product-category/mechanical-3d-puzzles/